Cincinnati Reds vs Pittsburgh Pirates 9/28/2022 Picks Predictions Previews The Cincinnati Reds will go against the Pittsburgh Pirates in MLB action in PNC Park, PA, on Wednesday, September 28, 2022, at 12:35 PM ET. In both baseball and the National League, the Pittsburgh Pirates had the second-worst performance. Even before they moved away a number of players before the trade deadline, the season was already a loss. They dropped to the basement of the NL Central going into this series after losing 9 of their previous 10 games. They rank 29th in batting average, 27th in runs scored, and 17th in home runs. On Wednesday, Bryse Wilson will start for the Pirates. Wilson, a right-hander, had 23 total appearances and 19 starts this season, going 3-9 with a 5.95 ERA. In 104.1 innings thrown, he walked 29 times and struck out 72 times. The Pirates’ 4.70 team ERA places them 26th in the league. The Pirates’ bullpen has the worst ERA in the majors, at 4.84. The total went UNDER in 9 of Cincinnati’s last 11 matches. The Cincinnati Reds are 1-5 SU in their previous 6 matches. Cincinnati is 0-6 SU in their last 6 matches against the Pittsburgh Pirates.